Brianza MONICA Study

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Datasets -
Variables -
Start Year
1986
Supplementary Information
The Brianza MONICA study was conducted by the Research Centre for Chronic Degenerative Diseases, Department of Internal Medicine, Department of Prevention and Health Biotechnology, University of Milan-Bicocca, Italy.
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Members

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Investigators Contacts
  • Professor Giovanni Veronesi
    University of Insubria
  • Professor Marco Ferrario
    University of Insubria
  • Professor Giancarlo Cesana
    Research Centre on Chronic Degenerative Diseases
  • Professor Paolo Brambilla
    Head of the laboratory, Desio Hospital
  • Professor Giovanni Veronesi
    University of Insubria

Design

Study design
Cohort
Follow Up
Each municipality was contacted in the beginning of 1999, in 2004 and in 2011 for information about emigration from the municipality, present residency and vital status (mortality follow-up covers the whole country). In Lombardia Region, hospital discharge records are available since 1987 and was used as the source of identification of nonfatal coronary and stroke events. Deaths are followed up locally beyond the time period covered in the MORGAM data.
Supplementary Information
Deaths and cardiovascular events are followed up for the harmonized MORGAM data, see detailed information on follow-up procedures used for in the MORGAM e-publication.

Marker Paper

Prediction of coronary events in a low incidence population. Assessing accuracy of the CUORE Cohort Study prediction equation. Ferrario MM, Chiodini P, Chambless LE, Cesana G, Vanuzzo D, Panico S, Sega R, Pilotto L, Palmieri L, Giampaoli S; CUORE Project Research Group. Int J Epidemiol. 2005 Apr;34(2):413-21. doi: 10.1093/ije/dyh405. Epub 2005 Jan 19. PMID: 15659467

Exploring the interplay between job strain and different domains of physical activity on the incidence of coronary heart disease in adult men. Ferrario MM, Veronesi G, Roncaioli M, Holtermann A, Krause N, Clays E, Borchini R, Grassi G, Cesana G; Cohorts Collaborative Study in Northern Italy (CCSNI) Research Group. Eur J Prev Cardiol. 2019 Nov;26(17):1877-1885. doi: 10.1177/2047487319852186. Epub 2019 May 20. PMID: 31109187

Decomposing the educational gradient in allostatic load across European populations. What matters the most: differentials in exposure or in susceptibility? Veronesi G, Kee F, Hicks B, Forrest H, Tunstall-Pedoe H, Kuulasmaa K, Sans S, Salomaa V, Thorand B, Di Castelnuovo A, Soderberg S, Cesana G, Bobak M, De Ponti R, Iacoviello L, Palmieri L, Zeller T, Blankenberg S, Ferrario MM. J Epidemiol Community Health. 2020 Dec;74(12):1008-1015. doi: 10.1136/jech-2020-213946. Epub 2020 Aug 27. PMID: 32855263

Determinants of social inequalities in stroke incidence across Europe: a collaborative analysis of 126?635 individuals from 48 cohort studies. Ferrario MM, Veronesi G, Kee F, Chambless LE, Kuulasmaa K, Jørgensen T, Amouyel P, Arveiler D, Bobak M, Cesana G, Drygas W, Ferrieres J, Giampaoli S, Iacoviello L, Nikitin Y, Pajak A, Peters A, Salomaa V, Soderberg S, Tamosiunas A, Wilsgaard T, Tunstall-Pedoe H; MORGAM Project. J Epidemiol Community Health. 2017 Dec;71(12):1210-1216. doi: 10.1136/jech-2017-209728. Epub 2017 Oct 5. PMID: 28983063

PUBMED ?term=15659467%5BPMID%5D+OR+31109187%5BPMID%5D+OR+32855263%5BPMID%5D+OR+28983063%5BPMID%5D

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
4,932
Number of participants with biosamples
4,783

Data Access

Availability of data and biosamples

Data
Biosamples
Other

Description of the access procedures

Access to the local data and biosamples is approved on a case-by-case basis. For more information about data request please contact the study representative.

For access to the harmonized MORGAM data from many MORGAM Centres, one should seek a collaboration with any of the Centre which can submit a publication proposal to the MORGAM/BiomarCaRE Steering Group.


Availability of access information

By contacting the study representative

Timeline

Populations

Selection Criteria
Minimum age
25
Maximum age
65
Countries
  • Italy
Territory
Brianza, seven health districts in historical area between Milan and Swiss border.
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information

Number of participants

Number of participants
1,659
Number of participants with biosamples
1,616
Supplementary Information
Response rate to the baseline survey was 69%.
Data Collection Events
# Name Description Start End
0 Brianza MONICA Study Cohort 01 Baseline Baseline examination (questionnaire and health examination). Biomarkers have been measured in BiomarCaRE Project. Genomics, transcriptomics ... 1986-04 1987-03
1 Brianza MONICA Study Cohort 01 mortality and disease outcome follow-up in MORGAM data Follow-up for cardiovascular events and death in the harmonized MORGAM data, see the end-points followed up in [a MORGAM e-publication](https://www.thl.fi/publications/morgam/cohorts/full/italy/ita... 1986-04 2008-12
2 Brianza MONICA Study Cohort 01 local mortality follow-up Deaths are followed locally up to the end of 2017. 1986-04 2017-12
Selection Criteria
Minimum age
25
Maximum age
66
Countries
  • Italy
Territory
Brianza, seven health districts in historical area between Milan and Swiss border.
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information

Number of participants

Number of participants
1,599
Number of participants with biosamples
1,523
Supplementary Information
Response rate to the baseline survey was 67%.
Data Collection Events
# Name Description Start End
0 Brianza MONICA Study Cohort 02 Baseline Baseline examination (questionnaire and health examination). Biomarkers have been measured in BiomarCaRE Project. Metabochip and Exome+ ... 1989-05 1990-07
1 Brianza Study Cohort 02 mortality and disease outcome follow-up in MORGAM data Follow-up for cardiovascular events and death in the harmonized MORGAM data, see the end-points followed up in [a MORGAM e-publication](https://www.thl.fi/publications/morgam/cohorts/full/italy/ita... 1989-05 2008-12
2 Brianza MONICA Study Cohort 02 local mortality follow-up Deaths are followed locally up to the end of 2017. 1989-05 2017-12
Selection Criteria
Minimum age
26
Maximum age
66
Countries
  • Italy
Territory
Brianza, seven health districts in historical area between Milan and Swiss border.
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information

Number of participants

Number of participants
1,674
Number of participants with biosamples
1,644
Supplementary Information
Response rate to the baseline survey was 69%.
Data Collection Events
# Name Description Start End
0 Brianza MONICA Study Cohort 03 Baseline Baseline examination (questionnaire and health examination). Biomarkers have been measured in BiomarCaRE Project. Metabochip and Exome+ ... 1993-09 1994-11
1 Brianza MONICA Study Cohort 03 mortality and disease outcome follow-up in MORGAM data Follow-up for cardiovascular events and death in the harmonized MORGAM data, see the end-points followed up in [a MORGAM e-publication](https://www.thl.fi/publications/morgam/cohorts/full/italy/ita... 1993-09 2008-12
2 Brianza MONICA Study Cohort 03 local mortality follow-up Deaths are followed locally up to the end of 2017. 1993-09 2017-12
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