Baseline examination (questionnaire and health examination). People aged 18-29 only participated in the interview and filled out a basic questionnaire. The main content covered in the questionnaire were functional capacity, quality of life and income, common symptoms, weight and height, time use and leisure activities, physical exercise, alcohol use, health promotion, living environment, psychological experiences, mood and feelings, as well as job perception and job strain. The interview on mental health disorders or symptoms focused on four principal categories: mood disorders, substance addiction, psychoses and anxiety disorders. The participants were asked to describe their ordinary diet over the past 12 months in the dietary questionnaire (semi-quantitative FFQ). In the health examination blood pressure and heart rate were measured and rest ECG recorded, basic anthropometric measurements were taken, including height, body circumference measurements and sagittal body measure. Spirometry was taken and bioimpedance was measured. The health examination included a clinical and radiographic examination of the mouth. For the measurement of functional capacity, tests were carried out on eyesight and hearing, cognitive functioning, balance, perceptual-motor speed and hand grip strength. Ultrasound examination of calcaneal bone was performed. Samples of whole blood, serum, lithium heparin plasma and spot urine were collected from all subjects, faeces and saliva samples were obtained from a subsample of subjects. Imputed genotype data, chip genotypes, telomeres and metabolomics are available. This data collection event is identified by the round number 01 of the FIN-H2K Cohort 21 in the harmonized MORGAM data. For the data available locally, please see the [website of THL Biobank](https://thl.fi/en/web/thl-biobank/for-researchers/sample-collections/health-2000-and-2011-surveys) where the local variables are described in detail. The questionnaire forms used are available in the [webpage of the THL](https://thl.fi/en/web/thlfi-en/research-and-development/research-and-projects/health-2000-2011/forms/health-2000-forms) for download.

Re-examination of the H2000 cohort (questionnaire and health examination). The content covered in the questionnaire were sociodemographic factors, financial situation, living and working conditions, work ability, functional capacity, quality of life, common symptoms, weight and height, lifestyle, time use and leisure activities, physical exercise, alcohol use, health promotion, psychological experiences, mood and feelings, as well as job perception and job strain. The interview on mental health disorders or symptoms focused on depressive, anxiety and alcohol use disorders and psychotic symptoms. There were several questions on dietary habits in the interview. In the health examination blood pressure and heart rate were measured and resting ECG recorded, basic anthropometric measurements were taken, including weight, height, and body circumference measurements. Spirometry was taken and bioimpedance was measured. The clinical oral health examinations were carried out in two out of the five field examination areas. Several performance tests measuring mobility, strength, balance and joint functions were conducted. Samples of whole blood, serum, lithium heparin plasma and EDTA plasma were collected from all participants. DNA was collected in the substudy. Imputed genotype data, chip genotypes, and metabolomics are available. This data collection event is identified by the round number 02 of the FIN-H2K Cohort 21 in the harmonized MORGAM data. Those participants that were examined first time in 2011 have the entry number 02. For the data available locally, please see the [website of THL Biobank](https://thl.fi/en/web/thl-biobank/for-researchers/sample-collections/health-2000-and-2011-surveys) where the local variables are described in detail. The questionnaire forms used are available in the [webpage of the THL](https://thl.fi/en/web/thlfi-en/research-and-development/research-and-projects/health-2000-2011/forms/health-2011-forms) for download.

Local follow-up of the participants through registry linkage. The data of the Finnish national health registers (e.g., mortality, cancer, health care and medicines) can be linked for all participants by request through [the Findata-process](https://thl.fi/en/web/thl-biobank/for-researchers/application-process/access-to-national-register-data). For the endpoint data available locally, please see the [website of THL Biobank](https://thl.fi/en/web/thl-biobank/for-researchers/sample-collections/health-2000-and-2011-surveys) where the register-based endpoint data are described in detail.