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PRIME Study

Datasets -
Variables -
Start Year
1991
Supplementary Information
The PRIME Study in Belfast was conducted by the Queen's University of Belfast, Centre for Public Health, Institute of Clinical Science, Northern Ireland, UK. The PRIME Study in Strasbourg was conducted by the Department of Epidemiology and Public Health, University of Strasbourg, France. The PRIME Study in Toulouse was conducted by the Department of Epidemiology, National Institute of Health and Medical Research, Unit 558, Toulouse, France. The PRIME Study in Lille was conducted by the French National Institute of Health and Medical Research (INSERM), Pasteur Institute, Lille, France.
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Members

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Investigators Contacts
  • Frank Kee
    The Queen's University of Belfast
  • MD, PhD Philippe Amouyel
    Lille University, Institut Pasteur de Lille, INSERM
  • Professor Jean Ferrieres
    Faculty of Medicine, Toulouse-Purpan
  • Dominique Arveiler
    University of Strasbourg
  • MD Marie Moitry
    University of Strasbourg
  • MD Marie Moitry
    University of Strasbourg
  • Professor Jean Ferrieres
    Faculty of Medicine, Toulouse-Purpan
  • MD, PhD Philippe Amouyel
    Lille University, Institut Pasteur de Lille, INSERM

Design

Study design
Cohort
Follow Up

In Belfast, deaths were obtained from the Business Services Organisation (BSO) and the General Register Office. Annual Follow-up Questionnaire was sent to all participants each year and some of the answers to this questionnaire led to further enquiry for hospitals/GPs.

In Strasbourg, Toulouse and Lille, deaths were obtained from the town hall or municipal corporation of the city (birth place). Annual Follow-up Questionnaire was sent to all participants each year and some of the answers to this questionnaire led to further enquiry for hospitals/GPs.

Supplementary Information

Deaths and cardiovascular events are followed up in all cohorts for the harmonized MORGAM data. Diabetes and cancers are additionally followed up for the PRIME Belfast cohort. See the detailed information on follow-up procedures used for MORGAM data in the cohort descriptions in the MORGAM e-publication (separate pages for Belfast, Strasbourg, Toulouse, and Lille).

For PRIME Belfast, deaths are followed up locally beyond the time period covered in the MORGAM data.

Marker Paper

PRIME Study Group (prepared by Yarnell JWG). The PRIME Study: classical risk factors do not explain the several fold differences in risk of coronary heart disease between France and Northern Ireland. Q J Med. 1998; 91: 667-676.

PUBMED 10024924

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
10,600
Number of participants with biosamples
3,000

Data Access

Availability of data and biosamples

Data
Biosamples
Other

Description of the access procedures

Access to the local data and biosamples is approved on a case-by-case basis. For more information about data request please contact the study representative.

For access to the harmonized MORGAM data from many MORGAM Centres, one should seek a collaboration with any of the Centre which can submit a publication proposal to the MORGAM/BiomarCaRE Steering Group.


Availability of access information

By contacting the study representative

Yes
No
Not applicable
Don't know

Timeline

Populations

Selection Criteria
Gender
men
Minimum age
50
Maximum age
59
Countries
  • France
Territory
Lille, group of 86 towns in northern France
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information

Number of participants

Number of participants
2,633
Number of participants with biosamples
0
Data Collection Events
# Name Description Start End
0 PRIME Lille Baseline

Baseline examination (questionnaire and health examination)

Metabochip and Exome+ genotyping (GWA studies) has been done for the case-cohort selection.		 1991-05 1993-03
1 PRIME Lille Mortality and disease outcome follow-up in MORGAM data

Follow-up for cardiovascular events and death. See the end-points followed up in the MORGAM e-publication. ...

 1991-05 2003-03
Selection Criteria
Gender
men
Minimum age
49
Maximum age
60
Countries
  • France
Territory
Toulouse, Haute Garonne, southern France bordering the Pyrenees
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information

Number of participants

Number of participants
2,610
Number of participants with biosamples
Data Collection Events
# Name Description Start End
0 PRIME Toulouse Baseline Baseline examination (questionnaire and health examination) Metabochip and Exome+ genotyping (GWA studies) has been done for the case-cohort selection. 1991-06 1993-04
1 PRIME Toulouse Mortality and disease outcome follow-up in MORGAM data

Follow-up for cardiovascular events and death. See the end-points followed up in MORGAM e-publication. ...

 1991-06 2003-04
Selection Criteria
Gender
men
Minimum age
50
Maximum age
59
Countries
  • France
Territory
Strasbourg, Bas-Rhin, north half of Alsace, north-eastern France
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information

Number of participants

Number of participants
2,612
Number of participants with biosamples
Supplementary Information
Response rate to the baseline survey was 80%.
Data Collection Events
# Name Description Start End
0 PRIME Strasbourg Baseline

Baseline examination (questionnaire and health examination)

Metabochip and Exome+ genotyping (GWA studies) has been done for the case-cohort selection.		 1991-11 1993-12
1 PRIME Strasbourg Mortality and disease outcome follow-up in MORGAM data

Follow-up for cardiovascular events and death. See the end-points followed up in MORGAM e-publication. ...

 1991-11 2003-12
Selection Criteria
Gender
men
Minimum age
49
Maximum age
60
Countries
  • United Kingdom
Territory
Belfast, Castlereagh, North-Down, and Ards Health Districts in east of Northern Ireland.
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information

Number of participants

Number of participants
2,745
Number of participants with biosamples
2,706
Supplementary Information
Response rate to the baseline survey was 52%.
Data Collection Events
# Name Description Start End
0 PRIME Belfast Baseline Baseline examination (questionnaire and health examination) Biomarkers have been measured in MORGAM Biomarker SubStudy and the BiomarCaRE ... 1991-06 1994-03
1 PRIME Belfast Local mortality follow-up Deaths are followed up to July 2021 locally (1366 of the 2745 were deceased at this date). 1991-06 2021-07
2 PRIME Belfast Mortality and disease outcome follow-up in MORGAM data

Follow-up for cardiovascular events, type 2 diabetes, cancers and death. See the end-points followed up in MORGAM ...

 1991-06 2012-01
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